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Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 480-484 doi: 10.1007/s11684-009-0083-9

摘要： The effects of compound Sophorae Flavescentis Jiechangrong capsule (CSFJC) on the expression of nuclear factor-κB p65 (NF-κB p65) and signal transducer and activator of transcription 6 (STAT6) in the intestinal mucosa of patients with ulcerative colitis and the possible mechanism were investigated. Eighteen patients with ulcerative colitis were randomly divided into a traditional Chinese medicine (TCM) group ( = 11) treated by CSFJC and a western medicine (WM) group ( = 7) treated by Sulfasalazine tablets. The treatment duration lasted eight weeks. Before and after the treatment, the symptoms and the physical signs were observed, and the routine stool test, the colonoscopy, and pathological examination were performed in the two groups. The expression levels of NF-κBp65 and STAT6 were detected by using immunohistochemistry. The results showed that the total effective rate of the curative effectiveness in TCM and WM groups was 100% and 71.4%, respectively, and the total effective rate of colonic mucosa lesion in TCM and WM groups was 90.9% and 71.4%, respectively, with the differences being significant (all < 0.05). The total effective rate of syndromes of damp-heat blocking according to the TCM in TCM and WM groups was 90.9% and 71.4%, respectively. After the treatment, the expression of NF-κB p65 and STAT6 in the two groups was decreased, and the decrease of NF-κB p65 and STAT6 expression in TCM group was more significant than in WM group ( < 0.05). It was concluded that CSFJC can inhibit the activation and expression of NF-κB p65 and STAT6 in the intestinal mucosa of patients with ulcerative colitis, which is a possible mechanism for CSFJC treating ulcerative colitis.

关键词： colitis     ulcerative     compound Sophorae Flavescentis Jiechangrong capsule     nuclear factor-κ     B p65 (NF-κ     B p65)     signal transducer and activator of transcription 6 (STAT6)    

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Computational modeling of fracture in capsule-based self-healing concrete: A 3D study

《结构与土木工程前沿（英文）》 2021年 第15卷 第6期   页码 1337-1346 doi: 10.1007/s11709-021-0781-1

摘要： We present a three-dimensional (3D) numerical model to investigate complex fracture behavior using cohesive elements. An efficient packing algorithm is employed to create the mesoscale model of heterogeneous capsule-based self-healing concrete. Spherical aggregates are used and directly generated from specified size distributions with different volume fractions. Spherical capsules are also used and created based on a particular diameter, and wall thickness. Bilinear traction-separation laws of cohesive elements along the boundaries of the mortar matrix, aggregates, capsules, and their interfaces are pre-inserted to simulate crack initiation and propagation. These pre-inserted cohesive elements are also applied into the initial meshes of solid elements to account for fracture in the mortar matrix. Different realizations are carried out and statistically analyzed. The proposed model provides an effective tool for predicting the complex fracture response of capsule-based self-healing concrete at the meso-scale.

关键词： 3D fracture     self-healing concrete     spherical     cohesive elements     heterogeneous    

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Steam reforming of toluene as a tar model compound with modified nickel-based catalyst

Omeralfaroug KHALIFA, Mingxin XU, Rongjun ZHANG, Tahir IQBAL, Mingfeng LI, Qiang LU

《能源前沿（英文）》 2022年 第16卷 第3期   页码 492-501 doi: 10.1007/s11708-021-0721-8

摘要： Catalytic steam reforming is a promising route for tar conversion to high energy syngas in the process of biomass gasification. However, the catalyst deactivation caused by the deposition of residual carbon is still a major challenge. In this paper, a modified Ni-based Ni-Co/Al O -CaO (Ni-Co/AC) catalyst and a conventional Ni/Al O (Ni/A) catalyst were prepared and tested for tar catalytic removal in which toluene was selected as the model component. Experiments were conducted to reveal the influences of the reaction temperature and the ratio between steam to carbon on the toluene conversion and the hydrogen yield. The physicochemical properties of the modified Ni-based catalyst were determined by a series of characterization methods. The results indicated that the Ni-Co alloy was determined over the Ni-Co/AC catalyst. The doping of CaO and the presence of Ni-Co alloy promoted the performance of toluene catalytic dissociation over Ni-Co/AC catalyst compared with that over Ni/A catalyst. After testing in steam for 40 h, the carbon conversion over Ni-Co/AC maintained above 86% and its resistance to carbon deposition was superior to Ni/A catalyst.

关键词： catalytic steam reforming     tar model compound     Ni-based catalyst     carbon resistance    

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Shear stress distribution prediction in symmetric compound channels using data mining and machine learning

Zohreh SHEIKH KHOZANI, Khabat KHOSRAVI, Mohammadamin TORABI, Amir MOSAVI, Bahram REZAEI, Timon RABCZUK

《结构与土木工程前沿（英文）》 2020年 第14卷 第5期   页码 1097-1109 doi: 10.1007/s11709-020-0634-3

摘要： Shear stress distribution prediction in open channels is of utmost importance in hydraulic structural engineering as it directly affects the design of stable channels. In this study, at first, a series of experimental tests were conducted to assess the shear stress distribution in prismatic compound channels. The shear stress values around the whole wetted perimeter were measured in the compound channel with different floodplain widths also in different flow depths in subcritical and supercritical conditions. A set of, data mining and machine learning algorithms including Random Forest (RF), M5P, Random Committee, KStar and Additive Regression implemented on attained data to predict the shear stress distribution in the compound channel. Results indicated among these five models; RF method indicated the most precise results with the highest value of 0.9. Finally, the most powerful data mining method which studied in this research compared with two well-known analytical models of Shiono and Knight method (SKM) and Shannon method to acquire the proposed model functioning in predicting the shear stress distribution. The results showed that the RF model has the best prediction performance compared to SKM and Shannon models.

关键词： compound channel     machine learning     SKM model     shear stress distribution     data mining models    

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Capsule endoscopy—A mechatronics perspective

Lin LIN, Mahdi RASOULI, Andy Prima KENCANA, Su Lim TAN, Kai Juan WONG, Khek Yu HO, Soo Jay PHEE

《机械工程前沿（英文）》 2011年 第6卷 第1期   页码 33-39 doi: 10.1007/s11465-011-0203-5

摘要：

The recent advances in integrated circuit technology, wireless communication, and sensor technology have opened the door for development of miniature medical devices that can be used for enhanced monitoring and treatment of medical conditions. Wireless capsule endoscopy is one of such medical devices that has gained significant attention during the past few years. It is envisaged that future wireless capsule endoscopies replace traditional endoscopy procedures by providing advanced functionalities such as active locomotion, body fluid/tissue sampling, and drug delivery. Development of energy-efficient miniaturized actuation mechanisms is a key step toward achieving this goal. Here, we review some of the actuators that could be integrated into future wireless capsules and discuss the existing challenges.

关键词： wireless capsule endoscopy     ingestible medical device     in-body medical device     medical robot     miniature actuator    

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R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

《医学前沿（英文）》 2022年 第16卷 第6期   页码 932-945 doi: 10.1007/s11684-022-0963-9

摘要： The dysfunction of Na+-Cl− cotransporter (NCC) caused by mutations in solute carrier family12, member 3 gene (SLC12A3) primarily causes Gitelman syndrome (GS). In identifying the pathogenicity of R158Q and G212S variants of SLC12A3, we evaluated the pathogenicity by bioinformatic, expression, and localization analysis of two variants from a patient in our cohort. The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensional structure. Western blot showed a decrease of mutant Ncc. Immunofluorescence of the two mutations revealed a diffuse positive staining below the plasma membrane. Meanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCC R158Q/G212S. NccR156Q/G210S mice clearly exhibited typical GS features, including hypokalemia, hypomagnesemia, and increased fractional excretion of K+ and Mg2+ with a normal blood pressure level, which made NccR156Q/G210S mice an optimal mouse model for further study of GS. A dramatic decrease and abnormal localization of the mutant Ncc in distal convoluted tubules contributed to the phenotype. The hydrochlorothiazide test showed a loss of function of mutant Ncc in NccR156Q/G210S mice. These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of GS.

关键词： Gitelman syndrome     mouse model     compound heterozygous     hypokalemia     Slc12a3    

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A compound load simulator based on zero-torsion parallel mechanisms

Jingjun YU, Wei LI, Xu PEI, Shusheng BI, Guanghua ZONG

《机械工程前沿（英文）》 2012年 第7卷 第1期   页码 1-4 doi: 10.1007/s11465-012-0306-7

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Engineering practice of mechanical soil aeration for the remediation of volatile organic compound-contaminated

Yan Ma, Xiaoming Du, Yi Shi, Deyi Hou, Binbin Dong, Zhu Xu, Huiying Li, Yunfeng Xie, Jidun Fang, Zheng Li, Yunzhe Cao, Qingbao Gu, Fasheng Li

《环境科学与工程前沿（英文）》 2016年 第10卷 第6期 doi: 10.1007/s11783-016-0870-x

摘要： Engineering practice of mechanical soil aeration in China is reviewed. MSA is a cost-effective technique for VOC-contaminated sites. Limitations of MSA application have been summarized. In recent years, many industrial enterprises located in the urban centers of China have been relocated owing to the rapid increase in urban development. At the sites abandoned by these enterprises, volatile organic compounds have frequently been detected, sometimes at high concentrations, particularly at sites abandoned by chemical manufacturing enterprises. With the redevelopment of sites and changes in land-use type associated with these sites, substantial amounts of contaminated soils now require remediation. Since China is a developing country, soil remediation warrants the usage of techniques that are suitable for addressing the unique challenges faced in this country. Land shortage is a common problem in China; the large numbers of contaminated sites, tight development schedules, and limited financial resources necessitate the development of cost-effective methods for land reclamation. Mechanical soil aeration is a simple, effective, and low-cost soil remediation technique that is particularly suitable for the remediation of large volatile organic compound-contaminated sites. Its effectiveness has been confirmed by conducting laboratory studies, pilot tests, and full-scale projects. This study reviews current engineering practice and developmental trends of mechanical soil aeration and analyzes the advantages and disadvantages of this technology for application in China as an emerging soil remediation market. The findings of this study might aid technology development in China, as well as assist other developing countries in the assessment and implementation of cost-effective hazardous waste site soil remediation programs.

关键词： Soil contamination     Volatile organic compound     Mechanical soil aeration     Engineering practice     China    

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绿色化的磷复肥生产集成工艺

冯怡生

《中国工程科学》 1999年 第1卷 第1期   页码 58-62

摘要：

磷复肥生产排放的磷石膏废渣堆存占地，污染环境，已成为亟待解决的难题。利用磷石膏制硫酸与水泥，可消除污染，实现硫资源的良性循环，使经济效益、社会效益和环境效益有机统一，促进了磷复肥工业的可持续发展。

关键词： 磷复肥     磷石膏     硫酸     水泥    

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A fast compound direct iterative algorithm for solving transient line contact elastohydrodynamic lubrication

null

《机械工程前沿（英文）》 2014年 第9卷 第2期   页码 156-167 doi: 10.1007/s11465-014-0297-7

摘要：

A fast compound direct iterative algorithm for solving transient line contact elastohydrodynamic lubrication (EHL) problems is presented. First, by introducing a special matrix splitting iteration method into the traditional compound direct iterative method, the full matrices for the linear systems of equations are transformed into sparse banded ones with any half-bandwidth; then, an extended Thomas method which can solve banded linear systems with any half-bandwidth is derived to accelerate the computing speed. Through the above two steps, the computational complexity of each iteration is reduced approximately from O(N3/3) to O(β2N), where N is the total number of nodes, and β is the half-bandwidth. Two kinds of numerical results of transient EHL line contact problems under sinusoidal excitation or pure normal approach process are obtained. The results demonstrate that the new algorithm increases computing speed several times more than the traditional compound direct iterative method with the same numerical precision. Also the results show that the new algorithm can get the best computing speed and robustness when the ratio, half-bandwidth to total number of nodes, is about 7.5%–10.0% in moderate load cases.

关键词： elastohydrodynamic lubrication     transient     line contact     matrix splitting iteration method     the Thomas method    

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复合式叶片型面测量系统的误差分析与补偿

李兵,陈磊,丁建军,蒋庄德

《中国工程科学》 2013年 第15卷 第1期   页码 39-44

摘要：

针对具有复杂型面的叶片类零件检测中所面临的数字化测量问题，提出了一种复合式的测量原理与方法。分别采用接触式的电感原理和非接触式的激光三角原理测量叶片的叶根基准以及叶身型面，并基于此原理设计研制了叶片型面四坐标测量系统。研究中结合该系统的机械结构特征，对影响其测量精度的各项几何误差进行了系统的分析，并提出了基于激光干涉测量的误差提取与补偿方法。实验结果表明，应用提出的误差分析与补偿方法可有效获取叶片型面四坐标测量系统的几何误差并显著提高其测量精度。

关键词： 叶片型面     复合式测量原理     误差分析     误差补偿     激光干涉测量    

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Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

《机械工程前沿（英文）》 2011年 第6卷 第1期   页码 3-12 doi: 10.1007/s11465-011-0209-z

摘要：

With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

关键词： personalized medical devices     wearable sensor     haptic device     ingestible medical capsule    

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硫酸盐岩与碳酸盐岩复合岩溶发育机理与工程效应研究

卢耀如,张凤娥

《中国工程科学》 2008年 第10卷 第4期   页码 4-10

摘要：

硫酸盐岩和碳酸盐岩常共同分布，以往多是分别研究其岩溶发育。文章主要从自然条件上研究两者复合岩溶发育的机理，探讨了化学岩溶作用过程和生物岩溶作用的机理。复合岩溶中，陷落柱是很重要的一个特征。文章也探索了复合岩溶作用中，有关岩溶地下水的水质情况。

关键词： 硫酸盐岩     碳酸盐岩     复合岩溶     陷落柱     地下水水质    

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Deep desulfurization of diesel fuels by catalytic oxidation

YU Guoxian, CHEN Hui, LU Shanxiang, ZHU Zhongnan

《化学科学与工程前沿（英文）》 2007年 第1卷 第2期   页码 162-166 doi: 10.1007/s11705-007-0030-8

摘要： Reaction feed was prepared by dissolving dibenzothiophene (DBT), which was selected as a model organosulfur compound in diesel fuels, in -octane. The oxidant was a 30 wt-% aqueous solution of hydrogen peroxide. Catalytic performance of the activated carbons with saturation adsorption of DBT was investigated in the presence of formic acid. In addition, the effects of activated carbon dosage, formic acid concentration, initial concentration of hydrogen peroxide, initial concentration of DBT and reaction temperature on the oxidation of DBT were investigated. Experimental results indicated that performic acid and the hydroxyl radicals produced are coupled to oxidize DBT with a conversion ratio of 100%. Catalytic performance of the combination of activated carbon and formic acid is higher than that of only formic acid. The concentration of formic acid, activated carbon dosage, initial concentration of hydrogen peroxide and reaction temperature affect the oxidative removal of DBT. The higher the initial concentration of DBT in the -octane solution, the more difficult the deep desulfurization by oxidation is.

关键词： organosulfur compound     performic     presence     activated     hydrogen peroxide    

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The effects of mismatch fracture properties in encapsulation-based self-healing concrete using cohesive-zone model

Luthfi Muhammad MAULUDIN, Chahmi OUCIF, Timon RABCZUK

《结构与土木工程前沿（英文）》 2020年 第14卷 第3期   页码 792-801 doi: 10.1007/s11709-020-0629-0

摘要： Finite element analysis is developed to simulate the breakage of capsule in capsule-based self-healing concrete. A 2D circular capsule with different core-shell thickness ratios embedded in the mortar matrix is analyzed numerically along with their interfacial transition zone. Zero-thickness cohesive elements are pre-inserted into solid elements to represent potential cracks. This study focuses on the effects of mismatch fracture properties, namely fracture strength and energy, between capsule and mortar matrix into the breakage likelihood of the capsule. The extensive simulations of 2D specimens under uniaxial tension were carried out to investigate the key features on the fracture patterns of the capsule and produce the fracture maps as the results. The developed fracture maps of capsules present a simple but valuable tool to assist the experimentalists in designing appropriate capsule materials for self-healing concrete.

关键词： self-healing concrete     interfacial zone     capsule materials     cohesive elements     fracture maps    

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标题 作者 时间 类型 操作

Effect of compound Sophorae Flavescentis Jiechangrong capsule on expression of NF-κB p65 and STAT6

Heng FAN MD, Jia ZHAO MM, Lin SHEN BM, Qing TANG MD, Zhexin SHOU MM, Li LIANG BM, Yi LIAO BM, Xiaoyan CHEN BM,

期刊论文

Computational modeling of fracture in capsule-based self-healing concrete: A 3D study

期刊论文

Steam reforming of toluene as a tar model compound with modified nickel-based catalyst

Omeralfaroug KHALIFA, Mingxin XU, Rongjun ZHANG, Tahir IQBAL, Mingfeng LI, Qiang LU

期刊论文

Shear stress distribution prediction in symmetric compound channels using data mining and machine learning

Zohreh SHEIKH KHOZANI, Khabat KHOSRAVI, Mohammadamin TORABI, Amir MOSAVI, Bahram REZAEI, Timon RABCZUK

期刊论文

Capsule endoscopy—A mechatronics perspective

Lin LIN, Mahdi RASOULI, Andy Prima KENCANA, Su Lim TAN, Kai Juan WONG, Khek Yu HO, Soo Jay PHEE

期刊论文

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

期刊论文

A compound load simulator based on zero-torsion parallel mechanisms

Jingjun YU, Wei LI, Xu PEI, Shusheng BI, Guanghua ZONG

期刊论文

Engineering practice of mechanical soil aeration for the remediation of volatile organic compound-contaminated

Yan Ma, Xiaoming Du, Yi Shi, Deyi Hou, Binbin Dong, Zhu Xu, Huiying Li, Yunfeng Xie, Jidun Fang, Zheng Li, Yunzhe Cao, Qingbao Gu, Fasheng Li

期刊论文

绿色化的磷复肥生产集成工艺

冯怡生

期刊论文

A fast compound direct iterative algorithm for solving transient line contact elastohydrodynamic lubrication

null

期刊论文

复合式叶片型面测量系统的误差分析与补偿

李兵,陈磊,丁建军,蒋庄德

期刊论文

Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

期刊论文

硫酸盐岩与碳酸盐岩复合岩溶发育机理与工程效应研究

卢耀如,张凤娥

期刊论文

Deep desulfurization of diesel fuels by catalytic oxidation

YU Guoxian, CHEN Hui, LU Shanxiang, ZHU Zhongnan

期刊论文

The effects of mismatch fracture properties in encapsulation-based self-healing concrete using cohesive-zone model

Luthfi Muhammad MAULUDIN, Chahmi OUCIF, Timon RABCZUK

期刊论文